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Clinical

HRT: breast cancer risk depends on formulation and duration of use

The risk that women using hormone replacement therapy (HRT) will develop breast cancer depends on the formulation and duration of use, a new analysis suggests.

Pharmacist interventions prevent pregnancy after EHC

Pharmacist interventions result in a significant increase in effective use of a contraceptive pill following emergency hormonal contraception.

Use of hormonal contraceptives linked to reduced asthma risk

A study claims the use of hormonal contraceptives may reduce the risk of severe asthma in women.

Most side effects of statins down to 'nocebo effect'

Most of the side-effects people suffer after taking statins are due to their negative associations with the drug, researchers have found.  

Ridge: Only use dexamethasone for oxygen patients

Dexamethasone should be used to treat patients with critical or severe Covid-19 but not patients with ‘non-severe’ illness, Keith Ridge says. 

Aspirin could protect against severe Covid-19

Taking aspirin may reduce the need for admission to an intensive care unit (ICU) and in-hospital mortality among people hospitalised with Covid-19.

Covid transmission no longer fastest in north of England

Covid infections doubling every nine days and R number up to 1.56.

Covid-19 antibody response wanes over time

Over three months the proportion of people who tested positive for antibodies declined by 26.5 per cent.

Intranasal spray may offer Covid protection, study suggests

An intranasal spray product using a mucoadhesive gel may offer some protection against coronavirus infection, new research suggests.

Once-promising Covid drug has ‘little to no survival impact’

Remdesivir – hailed in May as a potential breakthrough – has little impact on survival rates for patients hospitalised with the virus, says WHO.

Elevated INR seen in patients on anticoagulants during pandemic

MHRA warns that acute illness may exaggerate effect of warfarin tablets and necessitate dose reduction.

R number falling suggests latest data from REACT-1 coronavirus study

Study indicates R number could have fallen from 1.47  between 20 August to 26 September to around 1.06.

Over-50s suffering with loneliness at risk of diabetes

KCL study shows a strong relationship between loneliness and the later onset of type 2 diabetes

Discovery of four Covid-19 risk groups could help guide treatment

A risk identification tool uses the groupings to help clinical staff choose the best course of treatment for patients.

‘Immediate NHS action’ to safeguard hydrocortisone after Covid study

Seriously ill coronavirus patients have a better than 90 per cent chance of improved recovery when given a seven-day course of hydrocortisone.

Children with gastro problems should be tested for Covid-19

Researchers have called for children with gastrointestinal symptoms to be tested for Covid-19.

Clozapine toxicity in spotlight after two Coroners reports

Monitoring blood concentrations of clozapine for toxicity is now advised in certain clinical situations says MHRA.

Hypertension treatments could improve Covid survival rates

People with high blood pressure have a better chance of surviving Covid-19 if they are taking hypertension medications, research shows. 

Bipolar disorder tablets to be discontinued

Priadel 200mg and 400mg modified release tablets are to be discontinued, with all remaining supplies expected to run out by April of next year. 

Value of statins in the elderly confirmed

Starting statins reduces the risk of all-cause and cardiovascular mortality among people aged 75 years and older, a new study finds. 

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